1. We have recently discovered that, in Arabidopsis, members of the calmodulin-binding protein 60 (CBP60) family play important roles in signaling during responses to pathogens. Current work aims to understand the differential roles of family members, and the mechanisms by which these proteins affect activation of salicylic acid-dependent defenses. Salicylic acid-dependent defenses are critical for effective defense against biotrophic pathogens.
2. We are studying responses to the fungal necrotroph Alternaria brassicicola. From a metabolite profiling experiment, we have identified several metabolites that promote or restrict fungal growth. Very recently, we have begun testing the effects of alterations in plant cell walls on plant susceptibility to various pathogens. This could become important as crops with altered cell walls are bred for production of biofuels.
3. We are identifying pathogen proteins that are secreted into host cells from the wheat pathogen, Puccinia graminis pv. tritici. This work will ultimately lead to efforts to improve wheat resistance to this important pathogen.
We are grateful to NSF, DOE Biosciences, and the 2 Blades foundation for funding our work.
